AMD Instinct MI300X vs NVIDIA H100 SXM

A side-by-side comparison of specs, capabilities, and use cases.

By Fredoline Eruo·Last updated Jun 12, 2026·AMD Instinct MI300X·NVIDIA H100 SXM
SpecAMD Instinct MI300XNVIDIA H100 SXM
VRAM192 GB80 GB
Vendoramdnvidia
Tierworkstationworkstation
Power draw750 W700 W
Released20232022
Street price
CUDANoYes
ROCmYesNo
Metal / MLXNoNo

Frequently asked

Which is better, AMD Instinct MI300X or NVIDIA H100 SXM?

Neither is universally better — pick based on your specific need. AMD Instinct MI300X suits some workloads, NVIDIA H100 SXM suits others. The spec table above shows where each wins.

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