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RUNLOCALAI · v38
hardwares / AMD Instinct MI355X vs AMD Instinct MI325X

AMD Instinct MI355X vs AMD Instinct MI325X

A side-by-side comparison of specs, capabilities, and use cases.

By Eruo Fredoline·Last updated Jun 12, 2026·AMD Instinct MI355X·AMD Instinct MI325X
SpecAMD Instinct MI355XAMD Instinct MI325X
VRAM288 GB256 GB
Vendoramdamd
Tierworkstationworkstation
Power draw1000 W1000 W
Released20252024
Street price——
CUDANoNo
ROCmYesYes
Metal / MLXNoNo

Frequently asked

Which is better, AMD Instinct MI355X or AMD Instinct MI325X?

Neither is universally better — pick based on your specific need. AMD Instinct MI355X suits some workloads, AMD Instinct MI325X suits others. The spec table above shows where each wins.

Reviewed by RunLocalAI Editorial. See our editorial policy.