RunLocalAI
amd
GPU
128GB VRAM
workstation

AMD Instinct MI250X

Previous-gen CDNA 2. 128GB HBM2e. Powered the Frontier supercomputer.

Released 2021

Overview

Previous-gen CDNA 2. 128GB HBM2e. Powered the Frontier supercomputer.

Specs

VRAM128 GB
Power draw560 W
Released2021
MSRP$13000
Backends
ROCm

Models that fit

Open-weight models small enough to run on AMD Instinct MI250X with usable context.

Llama 3.1 8B Instruct
8B · llama
Qwen 3 30B-A3B
30B · qwen
Qwen 2.5 Coder 32B Instruct
32B · qwen
Llama 3.3 70B Instruct
70B · llama
Qwen 3 32B
32B · qwen
Gemma 4 31B Dense
31B · gemma
Qwen 3 8B
8B · qwen
DeepSeek R1 Distill Llama 70B
70B · deepseek

Frequently asked

What models can AMD Instinct MI250X run?

With 128GB VRAM, the AMD Instinct MI250X runs 70B models in 4-bit quantization, plus everything smaller. See the model list below for tested combinations.

Does AMD Instinct MI250X support CUDA?

No — AMD Instinct MI250X is an AMD card. Use ROCm (Linux) or the Vulkan backend in llama.cpp instead. CUDA-only tools won't work.

Reviewed by RunLocalAI Editorial. See our editorial policy for how we research and verify hardware specifications.